Benzodiazepine dependence is one of the quietest substance use stories in this country, and one of the most common. Benzodiazepines are a class of central nervous system depressant medications prescribed for anxiety, panic disorder, insomnia, seizure disorders, and muscle spasms. Commonly prescribed benzodiazepines include alprazolam (Xanax), clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and temazepam (Restoril). When used as prescribed for appropriate clinical indications, benzodiazepines can be effective medications. The problem is that they are among the most commonly prescribed medications in the United States, frequently prescribed for longer durations than clinical guidelines recommend, and capable of producing profound physical dependence even when taken exactly as directed.
For families across the Roanoke Valley, benzodiazepine dependence often began with a legitimate prescription for anxiety, panic, or insomnia. The treatment that follows requires careful clinical work because of the medical complexity of benzodiazepine discontinuation. Our treatment approach outlines the framework, and our admissions team coordinates the medically supervised taper with outside prescribers before or alongside PHP and IOP participation.
How Benzodiazepines Produce Dependence
Here is something we want every family with a Xanax or Klonopin bottle in the house to understand. Benzodiazepines enhance the effect of GABA, the brain’s primary inhibitory neurotransmitter, at GABA-A receptors throughout the central nervous system. With prolonged use, the brain adapts by reducing its own GABA production and upregulating excitatory glutamate systems. When benzodiazepines are removed, the resulting CNS hyperexcitability is the withdrawal syndrome, essentially a rebound of excessive neuronal firing that can range from uncomfortable to life-threatening. The neuroadaptation can develop within weeks of regular daily use, which is why benzodiazepine dependence is so common among people who began with a routine clinical prescription. You did not abuse anything. The medication did what the medication does.
Critical Safety Notice
Benzodiazepine Withdrawal: A Medical Emergency Without Supervision
This is the part most people in this situation are not told clearly enough. Benzodiazepine withdrawal is one of the most medically dangerous withdrawal syndromes of any substance, and the risks below are what make supervised discontinuation non-negotiable.
Generalized tonic-clonic seizures
Potentially life-threatening.
Status epilepticus
Prolonged, uncontrolled seizure activity requiring emergency intervention.
Delirium and severe cognitive disorganization
Often confused with primary psychiatric symptoms.
Extreme autonomic instability
Heart rate, blood pressure, and temperature dysregulation.
Psychosis in severe cases
Including hallucinations and delusional thinking.
These risks are why medically supervised discontinuation is the absolute standard of care, and why Roanoke Refuge coordinates with an outside prescribing physician before treatment begins for clients who are physically dependent on benzodiazepines.
The Standard of Care: Medically Supervised Taper
Slow is what works. We say that to every family who calls about benzodiazepines, because the impulse to rip the medication out fast is understandable and dangerous. The clinical standard for benzodiazepine discontinuation in physically dependent clients is a medically supervised taper, a gradual, controlled reduction in dose managed by a physician experienced in benzodiazepine discontinuation. The taper typically uses a longer-acting benzodiazepine such as diazepam as a conversion agent because of its more stable pharmacokinetic profile. A well-managed taper can take weeks to months and must not be rushed. Forcing a faster taper than the client’s neurobiology can tolerate increases the risk of seizure and withdrawal complications.
Our Treatment Approach for Benzodiazepine Use Disorder
Here is what the work looks like once the taper plan is in place. A treatment plan for clients with benzodiazepine use disorder typically includes the following.
Coordination with a prescribing physician
Medically supervised tapers are managed by the prescribing physician before and during outpatient programming, with our team coordinating around the taper plan.
Cognitive Behavioral Therapy
Addressing anxiety management, sleep hygiene, and stress regulation without pharmacological dependence. Learn more
Dialectical Behavior Therapy skills
For emotional regulation, distress tolerance, and the moments of high anxiety that previously drove benzodiazepine use. Learn more
Treatment of co-occurring anxiety disorders
The most common reason benzodiazepines were originally prescribed, and treating the underlying condition is essential to sustained recovery. Learn more
Psychoeducation
On benzodiazepine dependence, the taper process, the protracted withdrawal trajectory, and the recovery timeline.
Monitoring for protracted withdrawal
Symptoms can persist for weeks to months after completing the taper, and our clinical team tracks the trajectory through the post-taper window.
How We Treat This at Roanoke Refuge
Here is what to expect when you call us about a Klonopin or Xanax pattern. Clients with benzodiazepine use disorder require a supervised medical taper before or concurrent with participation in our PHP or IOP programs. Our admissions team coordinates with the client’s prescribing physician to establish a taper plan that fits the client’s specific neurobiology and history of use. Clinical treatment then focuses intensively on building the behavioral anxiety management skills, including CBT, DBT, and relaxation training, that reduce the perceived clinical need for benzodiazepines over time. The co-occurring anxiety disorder that often underlies benzodiazepine use is addressed directly and concurrently, because resolving the substance use without resolving the underlying anxiety leaves the original driver of the prescription intact. We do not ask anyone to choose between the panic and the prescription. We ask the panic to come into the room with us.
Dual Diagnosis and Benzodiazepine Use Disorder
The vast majority of clients with benzodiazepine use disorder have a primary anxiety disorder, panic disorder, or post-traumatic stress disorder that prompted the original prescription. Treating the benzodiazepine use without treating the underlying anxiety is like treating the smoke while leaving the fire burning. Our integrated dual diagnosis program addresses both at the same time, in the same setting, and by the same clinical team, with non-benzodiazepine pharmacological options coordinated through outside prescribers where appropriate.
Local, regional, and accessible.
Treatment for this substance is delivered from our Salem facility at 1630 Braeburn Drive — just off I-81 exit 137. The Roanoke Valley service area covers Roanoke City, Salem, Vinton, and the surrounding counties of Roanoke, Botetourt, and Bedford. The Salem VA Medical Center sits roughly two miles away and serves as a referral partner for veterans transitioning to civilian outpatient care.
The path in is a single phone call. The admissions team walks through fit, level of care, insurance, and what the first week of treatment will actually look like — at no cost and with no clinical commitment until you are ready. Insurance benefits get verified during the same call. Call (540) 900-0353 to start the conversation.